How Long Does Cialis Last 20 Mg: Preparations for treating Erectile Disorders Wikipedia

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How Long Does Cialis Last 20 Mg: Preparations for treating Erectile Disorders Wikipedia

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How Long Does Cialis Last 20 Mg: Preparations for treating Erectile Disorders Wikipedia

Preparations for the treatment of erectile dysfunction – Wikipedia

Endocrine disorders

hypogonadism or insufficient testosterone

age-related changes like age androgen deficiency

dysfunction of the thyroid gland, hyperprolactinemia, hypercorticism, etc.

damage to the pelvic nerves (for example, after removal of the prostate gland cost of cialis 5mg) [4]

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insufficient blood supply to the penis,

psychological problems [5].

side effects of already taken drugs (for example, antihypertensives),

lifestyle (excessive use of alcohol, drugs, smoking, stubborn masturbation) [6] [7]

Place of drugs in the system of treatment of erectile dysfunction [edit | edit code]

Preparations for treating erectile dysfunction are not the only method used to solve this problem. These methods include the following:

eliminating the cause of the erectile dysfunction,

exercise, especially aerobics [8]

How Long Does Cialis Last 20 Mg: Preparations for treating Erectile Disorders Wikipedia

medical advice. When a psychological reason for the inability to produce an erection is suspected or not excluded, as well as to help cope with a depressed condition, the cheapest cialis 20 mg is considered the need to give medical advice.

household drugs and medical drugs for the treatment of erectile dysfunction,

vacuum treatment, [9]

surgical methods [10].

As can be seen, in the first stages, when the reasons underlying the violation of the ability to perform sexual intercourse due to the absence of hardening of the penis, are eliminated, drugs, as a rule, do not apply. Rather, the underlying disease is treated and medical advice is given with medications.

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The mechanism of action of drugs for the treatment of impaired erection [edit | edit code]

The main group of drugs is phosphodiesterase 5 (PDE-5) inhibitors, one of the phosphodiesterase (PDE) cyclic nucleotides that catalyze the hydrolysis of cAMP and cGMP nucleotides. PDEs exist in different molecular forms and are unevenly distributed throughout the body: for example, PDE-1 is found in vascular smooth muscle fibers, brain, heart, lungs, and PDE-6 – in the retina. PDE-5 is found not only in the smooth muscle fibers of the cavernous bodies of the penis, but also in the lungs and gastrointestinal tract.

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When taking PDE-5 inhibitors, the action of the corresponding enzyme is blocked, which, in turn, leads to an increase in the number of cyclic GMP and relaxation of smooth cialis 40 mg reviews of the muscles in the arteries of the penis. The latter contributes to the filling of the cavernous bodies of the penis with blood. The drugs of this group have an effect only when the man is in sexual arousal, they do not lead to the appearance of where can i buy an erection in the absence of sexual arousal. Depending on the drug, take a pill for 20 minutes. – 1 hour before expected sexual intercourse. The drug may have an effect within 3-36 hours. Part of the physiological process that occurs during erection involves the release of nitric oxide in the circulatory network of the corpus cavernosum, as a result of sexual intercourse. Nitric oxide activates the enzyme guanylate cyclase, which is manifested in increased levels of cyclic guanosine monophosphate (cGMP), which leads to relaxation of smooth muscles in the blood vessels supplying the cavernous bodies to buy cialis online, leading to an increase in blood flow and erection.

Inhibitors of phosphodiesterase 5 inhibit the decomposition of cGMP using phosphodiesterase type 5 (PDE 5), increasing blood flow to the penis during sexual arousal. Additionally, the effectiveness of the action of nitric oxide, which physiologically dilates the blood vessels of the cavernous bodies in the penis, is enhanced.

Side effects of other drugs used to increase the onset of erection and increase its intensity [edit | edit code]

Probably the most commonly used drug is alcohol, which in low concentrations in the blood produces a disinhibition, and at high concentrations it impairs the ability to perform an erection. The use of tobacco (for example, smoking cigarettes) also suppresses sexual function; the incidence of impotence is 85% higher in male smokers compared to non-smokers. The use of certain androgenic hormones can also change the levels of sexual arousal and the levels of sexual aggression.

Many other drugs, both permitted for use and illegal, after cialis 20 mg price walgreens of prolonged use in order to increase the onset of erection and increase its intensity, have side effects, of which the most frequent was a decrease in sexual desire. For example, a number of prohibited drugs, known abroad as MDMA, enhance sensual and erotic sensations, although they suppress sexual intercourse itself by causing a temporary erectile dysfunction. Other similar drugs, such as GHB, are notorious for using to bring unsuspecting victims into a state of insensitivity or severe suppression and become easy prey for genital predators. Many antidepressants and anti-psychotic drugs have a side effect in the form of reduced sexual desire.

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History [edit | edit code]

How Long Does Cialis Last 20 Mg: Preparations for treating Erectile Disorders Wikipedia

The earliest attempts at treating disorders in the ability of a man’s penis to grow in size, solidify and straighten out for a period sufficient to perform sexual intercourse date from the era of Muslim doctors and pharmacists in the medieval Islamic world. They were the first to prescribe drugs for this problem and developed several methods for treating this condition, including a single drug-based or combination method, when they prescribed either a drug or a food product. Most of these drugs were oral, although some patients were also treated with local and transurethral methods. Among Muslim doctors and pharmacists were Muhammad ibn Zakaria Razi, Tabib bin Kura, Ibn Al-Jazzar, Avicenna (Canons of Medicine), Averroes, Ibn Al-Baitar and Ibn al-Nafis (Complete Book on Medicine). [11]

In the 1920s and 1930s in the United States, Dr. John R. Brinkley began the male healing boom of buying generic cialis impotence. His radio programs, as a way to restore masculine qualities, were recommended by expensive goat gland implants and injections of “mercurochrome”, including operations performed by surgeon Serge Voronoff. After the Kansas State Medical Committee revoked his medical license, and the Federal Radio Commission refused to extend its radio license (both episodes occurred in 1930), Brinkley moved cialis mg to Mexico directly across the Texas border, where he opened a medical clinic and from where he broadcast his ads in the USA with the help of a cross-border speaker.

Since the 1970s, surgeons have begun to provide patients with inflatable implants in the penis.

Modern medical therapy for erectile dysfunction has made significant progress in 1983, when British physiologist Giles Brindley | lowered his pants and demonstrated the erection of his penis caused by phentolamine to the shocked audience of the American Urological Association. The drug Brindley introduced to his penis was a nonspecific vasodilator alpha blocker, the mechanism of action of which was clearly due to the relaxation of smooth muscles in the body of the penis. The effect discovered by Brindley laid the foundation for the later development of specific, safe, oral-effective drug treatments [12].

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The systematic position of drugs for the treatment of erectile dysfunction [edit | edit buy cialis cheap code]

In the Anatomical, Therapeutic and Chemical Classification, these drugs are in

The main anatomical group G The urinary system and sex hormones,

Therapeutic-pharmacological group G04 Preparations for the treatment of urological diseases

The group of the drug G04BE Preparations for the treatment of erectile dysfunction [13]

Drugs used after the drugs for the treatment of impaired erection are ineffective [edit | edit code]

When this happens, vacuum means and surgical treatment are used to achieve an erection.

Vacuum treatments for impaired erections consist in placing the penis in a vacuum cylindrical cialis 5mg review device, which stimulates additional blood flow to the penis. The root of the penis size impose a compressive ring, which helps to maintain the achieved erection [14]. A device of this type is sometimes called a “pump” for the penis, it is used just before sexual intercourse. Several types of devices for vacuum treatment, approved by the Food and Drug Administration of the United States, are available on prescription. These types of pumps should be distinguished from pumps supplied without compression rings, which are used not for temporary generic cialis 20mg treatment of erectile dysfunction, but in claims to increase the length and volume of the penis with frequent use or for masturbation.

Surgical treatment is used if other methods have been ineffective. In a few cases, a vascular problem may be the basis of an erection disorder, then the reconstruction of the vascular system of the cavernous bodies is carried out. With a more thorough approach, surgically cialis 10mg price places inflatable or resilient implants, cartilages or silicone rods into the penis, which are irreversible and expensive. All these mechanical methods, based on simple principles of hydraulics and mechanics, are quite reliable, but have their own drawbacks [10].

Notes [edit | edit code]

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